Trying to stay sane despite rapid advances in scientific understanding and technology!
Showing posts with label glucose. Show all posts
Showing posts with label glucose. Show all posts

Friday, June 21, 2013

Sugar overload can damage the heart:



The glucose metabolite glucose 6-phosphate (G6P), causes stress to the heart that changes the muscle proteins and induces poor pump function leading to heart failure… G6P can accumulate from eating too much starch and/or sugar. [thank you editors for clarifying that indeed STARCH to can be a serious problem, not JUST that which tastes sweet!]

"When the heart muscle is already stressed from high blood pressure or other diseases, and then takes in too much glucose, it adds insult to injury," Taegtmeyer said.

The study has opened doors to possible new treatments. Two drugs, rapamycin (an immunosuppressant) and metformin (a diabetes medication) disrupt signaling of G6P and improved cardiac power in small animal studies.

"These drugs have a potential for treatment and this has now cleared a path to future studies with patients," Taegtmeyer said.

Getting enough sleep could help prevent type 2 diabetes



insulin sensitivity, the body's ability to clear glucose (blood sugar) from the bloodstream, significantly improved after three nights of "catch-up sleep" on the weekend in men with long-term, weekday sleep restrictions.

Reducing the incidence of this chronic illness is critical for a nation where diabetes affects nearly 26 million people and costs an estimated $174 billion annually."

The body of a patient with Type 2 diabetes cannot effectively use the insulin it produces, or it becomes "resistant" to insulin. Retaining the body's sensitivity to insulin reduces the risk of developing Type 2 diabetes, a chronic illness that is the seventh leading cause of death in the U.S.

Liu and researchers from the University of Sydney in Australia studied 19 non-diabetic men, with an average age of 28.6 years, who for six months or longer (average, 5.1 years) self-reported inadequate sleep during the workweek. On average, the men received only 6.2 hours of sleep each work night. But they regularly caught up on their sleep on the weekends, sleeping an extra 37.4 percent, or 2.3 hours, per night, the authors reported. Their reported sleep times were verified by actigraphy, in which each man wore a small device on his wrist that monitored sleep-wake cycles.
The men spent three nights in a sleep lab on each of two separate weekends. The researchers randomly assigned the men to two of three sleep conditions: (1) 10 hours of sleep, (2) six hours of sleep or (3) 10 hours in bed, in which noises during deep sleep aroused them into shallow sleep without waking them. The six hours of sleep tested persistent sleep restriction.

On the fourth morning, the research staff drew the men's blood to measure their blood sugar and insulin levels to calculate insulin sensitivity. Each individual had the same food intake during the study visits, so that diet would not influence the results, Liu said.

When the men slept 10 hours a night on each of three nights of catch-up sleep, their insulin sensitivity was much better than when they had persistent sleep restriction, the scientists found. Their insulin resistance test score also improved (decreased) with sleep extension.

Come on guys! Getting a good nights sleep should be the easiest and most enjoyable thing ever, not to mention it will improve your insulin sensitivity :O!

Thursday, June 13, 2013

High sugar intake = low dopamine release in the insulin resistant = model for addiction?

http://www.sciencedaily.com/releases/2013/06/130610223722.htm

For those with poor insulin sensitivity and raised blood glucose levels (hello type 2 diabetics) a sugary drink resulted in a lower-than-normal release of the chemical dopamine in... the
nucleus accumbens, where much of the brain's reward circuitry is located.

 After patients drank the sugary glucose, those who were insulin-resistant and had signs of disorderly eating were found to have remarkably lower natural dopamine release in response to glucose ingestion when compared with the insulin-sensitive control subjects.

"Animal studies indicated that increased insulin resistance precedes the lack of control associated with pathological overeating," said Wang. "They also showed that sugar ingestion releases dopamine in brain regions associated with reward. However, the central mechanism that contributes to insulin resistance, pathological eating and weight gain is unknown."