http://www.sciencedaily.com/releases/2013/06/130610133123.htm
The transformation of sedentary, specialized cells into wandering,
invasive, and unspecialized cells is called epithelial-mesenchymal
transition (EMT), which is central to metastasis.
Sox4 is upregulated in its activity and triggers the expression of a
number of genes that play an important role during EMT and metastasis.
In particular, Sox4 promotes the expression of the enzyme Ezh2, a
methyltransferase, which generally influences methylation of specific
proteins (histones), the packaging of the genetic material, and thus its
readability and gene expression.
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