Keatmines “cousin” [GLYX-13] rapidly lifts depression
without side effects:
“Human clinical studies demonstrated that ketamine can ward off major and bipolar depressive symptoms within 2 hours of administration and last for several days. Ketamine is fraught with serious side effects including excessive sleepiness, hallucinations, and substance abuse behavior.”
"Our drug, GLYX-13, is very different. It does not block the receptor ion channel, which may account for why it doesn't have the same side effects."
“Human clinical studies demonstrated that ketamine can ward off major and bipolar depressive symptoms within 2 hours of administration and last for several days. Ketamine is fraught with serious side effects including excessive sleepiness, hallucinations, and substance abuse behavior.”
"Our drug, GLYX-13, is very different. It does not block the receptor ion channel, which may account for why it doesn't have the same side effects."
“Previous electrophysiological and conditioning studies
had suggested that GLYX-13, unlike ketamine, enhanced memory and learning in
rats, particularly in the brain's memory hub or hippocampus. GLYX-13 also
produced analgesic effects.”
“GLYX-13 and ketamine produced rapid acting (1 hour) and
long-lasting (24 hour) antidepressant-like effects in the rats. Fluoxetine, an
SSRI that typically takes from 2-4 weeks to show efficacy in humans, did not
produce a rapid antidepressant effect in this study.”
“These results are consistent with data from a recent
Phase 2 clinical trial, in which a single administration of GLYX-13 produced
statistically significant reductions in depression scores in patients who had
failed treatment with current antidepressants. The reductions were evident
within 24 hours and persisted for an average of 7 days. After a single dose of
GLYX-13, the drug's antidepressant efficacy nearly doubled that seen with most
conventional antidepressants after 4-6 weeks of dosing. GLYX-13 was well
tolerated and it did not produce any of the schizophrenia-like effects
associated with other NMDA receptor modulating agents.”
“Moskal speculates that GLYX-13 either directly binds to
the glycine site on the NMDA receptor or indirectly modulates how glycine works
with the receptor. Resulting activation of more NMDA and AMPA receptors leads
to an increase in memory, learning -- and antidepressant effects. By contrast,
ketamine only blocks the NMDA receptor, but also increases the activity of the
AMPA receptor. Knowledge of these mechanisms could lead to the development of
more effective antidepressants.”
This reminds me of how SSRI’s are speculated to possibly
work through their effects on increasing brain derived neuro factor (BDNF) which
may in turn make one hypersusceptible to new learning, in turn allowing someone
in a rut to quickly learn a way out of it…
People are always suprised when I say Ketamine, horse tranquiliser, or special K as it is known in drug circles has beneficial properties. It was also shown in another study to have neuroregenerative effects:
http://www.sciencedaily.com/releases/2012/10/121004141747.htm
"In their research, Duman and others show that in a series of steps ketamine triggers release of neurotransmitter glutamate, which in turn stimulates growth of synapses. Research at Yale has shown that damage of these synaptic connections caused by chronic stress is rapidly reversed by a single dose of ketamine."
Though I've never used it, so I can't attest to this personally, but i'm all for the open study of drugs and there effects, both positive and negative.
People are always suprised when I say Ketamine, horse tranquiliser, or special K as it is known in drug circles has beneficial properties. It was also shown in another study to have neuroregenerative effects:
http://www.sciencedaily.com/releases/2012/10/121004141747.htm
"In their research, Duman and others show that in a series of steps ketamine triggers release of neurotransmitter glutamate, which in turn stimulates growth of synapses. Research at Yale has shown that damage of these synaptic connections caused by chronic stress is rapidly reversed by a single dose of ketamine."
Though I've never used it, so I can't attest to this personally, but i'm all for the open study of drugs and there effects, both positive and negative.
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