Trying to stay sane despite rapid advances in scientific understanding and technology!

Friday, June 21, 2013

Deep brain stimulation of the so-called “feeding centre” (the lateral hypothalamic area) was associated with weight loss via increased metabolism in morbidly obese patients



After nine months, one patient who had experienced a 9 percent increase in resting metabolic rate reduced his weight by 16.4 percent. Another patient, whose metabolic chamber metabolic rate change was indeterminate due to motion during the selected stimulation approach, lost 12.3 percent of her weight after 11 months at the optimal setting. The final patient had a 0.9 percent decrease after 16 months at optimal settings, but also commented that this was the first time in her life that she did not have to fight constant hunger, and her binge eating score reduced from severe to within normal range.

The team believes expanded research studies might show that optimal settings would reduce appetite and food cravings, as well… In order for survival during lean times, humans have evolved to automatically lower metabolic rate when food intake goes down -- an innate "set point" that can add challenge to weight-loss efforts. This work by Oh and colleagues suggests that the "set point" can be adjusted like a thermostat.

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